A Detailed Analysis of Individuals Having Graft Failure After Corneal Transplantation

ABSTRACT

Purpose

To describe demographic and clinical characteristics of patients with graft failure after keratoplasty, determine the cause of graft failure and outcomes.

Methods

The charts of patients between 2008–2013 in the Cornea Service at Wills Eye Hospital with a history of a corneal transplant before the end of 2012 were retrospectively reviewed. Included were patients who had graft failure after corneal transplantation and had at least one year of follow-up after transplantation. Penetrating keratoplasty (PK) and Descemet’s stripping endothelial keratoplasty (DSEK) patients were analyzed separately.

Results

A total of 186 eyes of 170 patients with graft failure after a PK (156) or DSEK (30) procedures were identified. The baseline characteristics included 100 female and 70 male patients with an age between 0 and 90 years (median 63 years). At the time of surgery, 38% had three or more systemic diseases and 68% were using three or more systemic medicines. Mean follow up time for PK was nearly four times of DSEK. Only 2 DSEK eyes (7%) underwent a 3rd DSEK graft, while 47 (30%) PK eyes underwent a 3^rd PK and 15 (10%) PK eyes underwent more than three PK procedures.

Conclusions

Most DSEK failures occurred in 1^st year, while graft failure in PKs is scattered over years. Failure in DSEK is mostly due to graft or surgical risk factors but in PK mostly due to factors in the host. DSEK does not appear to be as affected by the patients’ demographic and clinical characteristics as much as PK.

KEYWORDS:

• Corneal transplantation
• Descemet’s stripping endothelial keratoplasty
• graft failure
• penetrating keratoplasty

ACKNOWLEDGMENTS

The authors indicate no funding support. C.J.R. is a consultant for Allergan, Bausch and Lomb and Merck; and he is on the Speakers Bureau for Allergan, Alcon, Bausch and Lomb and Merck. Study has been presented at The American Academy of Ophthalmology in Las Vegas, Nevada, November 13-17, 2015.

DISCLOURE STATEMENT

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.