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Research Article

Two new jatrophane diterpenoids from Euphorbia helioscopia with activity towards autophagic flux

Ming-You Penga State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang550014, ChinaView further author information
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Xiong Zhanga State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang550014, ChinaView further author information
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Qin-Dan Lia State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang550014, ChinaView further author information
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En-Ming Fenga State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang550014, ChinaView further author information
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Lu Chena State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang550014, ChinaView further author information
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Hu-Cheng Yanga State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang550014, ChinaView further author information
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Bing Guob Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang550014, ChinaView further author information
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Ying-Tong Dic State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming650201, ChinaView further author information
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Lei Tanga State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang550014, ChinaView further author information
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Rong-Can Luod Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming650204, China;e Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, and Key Laboratory of Cell Activities and Stress Adaptations, Ministry of Education, School of Life Sciences, Lanzhou University, Lanzhou730000, ChinaCorrespondence[email protected]
View further author information
&
Ying Yana State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang550014, ChinaCorrespondence[email protected]
View further author information
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Received 27 Nov 2023, Accepted 15 Apr 2024, Published online: 16 May 2024
 
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Abstract

Nine jatrophane diterpenoids were isolated from the whole plant Euphorbia helioscopia, including two new ones, helioscopnins A (1) and B (2). Comprehensive spectroscopic data analysis and ECD calculations elucidated their structures, including absolute configurations. All compounds were evaluated for bioactivity towards autophagic flux by flow cytometry using HM mCherry-GFP-LC3 cells. Compounds 1, 3, 4, 5, 8, and 9 significantly increased autophagic flux.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

Financial support for this study was provided by National Natural Science Foundation of China (82360687 and 32170988), Guizhou Provincial Science and Technology Project (ZK [2022]393), Guizhou Province High Level Innovative Ten Level Talent Project (QKH [2023]002), Guizhou Provincial Natural Science Foundation ([2022]4017 and [2021]4029), Provincial College Student Innovation and Entrepreneurship Project (S202210660144)

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