Macrophorins H and L, two new HMG-conjugate macrophorins from rihzospheric Penicillium sp. NX-05-G-3

Abstract

Macrophorins H (4) and L (5), two rare HMG-conjugate macrophorins along with three known macrophorins (1-3), three DMOA-derived meroterpenoids (6-8) and two ergosterol derivates (9-10) were isolated from sterilized rice medium cultured Penicillium sp. NX-05-G-3. Their structures were elucidated by 1D and 2D NMR. The cytotoxicities of all compounds were evaluated, and compounds 1 and 2 showed extensive cytotoxicity against human cancer cell lines Hela, SCC15, MDA-MB-453 and A549, with IC₅₀ values ranging from 17.6 to 32.8 µM.

Keywords:

• Macrophorins
• meroterpenoids
• rhizosphere fungi, cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially sponsored by grants from the Science and Technology Research Program of Chongqing Municipal Education Commission (KJQN202201301, KJQN202301321), the Natural Science Foundation of Chongqing, China CSTC, 2020jcyj-msxmX0849 and the Scientific Research Foundation of the Chongqing University of Arts and Sciences (R2021SYX05, R2018SCH10 and P2019XY02).