Secofumitremorgins C and D, a pair of atropisomers from saltern-derived fungus Aspergillus fumigatus GXIMD00544

Abstract

A pair of atropisomers secofumitremorgins C (1a) and D (1b), together with fifteen known alkaloids (2-16), were isolated from a saltern-derived fungus Aspergillus fumigatus GXIMD00544. The structures of atropisomers 1a and 1b were elucidated by the detailed spectroscopic data, chemical reaction and quantum chemical calculations. Compounds 1 and 8 displayed antifungal spore germination effects against plant pathogenic fungus associated with sugarcane Fusarium sp. with inhibitory rates of 53% and 77% at the concentration of 100 µM, repectively. Atropisomers 1 also exhibited antifouling potential against Balanus amphitrite larval settlement with an inhibitory rate of 96% at the concentration of 100 µM.

Keywords:

• Saltern-derived fungus
• atropisomers
• alkaloids
• fungal spore germination
• antifouling

Acknowledgements

We would like to thank Ms. Hu-Mu Lu, Dr. Xian-Qiang Chen and Dr. Xiao Lin from Institute of Marine Drugs, Guangxi University of Chinese Medicine, for the collection of NMR and MS spectral data.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research was funded by Guangxi Natural Science Foundation (2020GXNSFGA297002, 2021GXNSFDA075010), National Natural Science Foundation of China (42066006, U20A20101, 32060098), Special Fund for Bagui Scholars of Guangxi (05019055); The Scientific Research Foundation of GXUCM (2022C011, 2022A007); Guangxi First-class Discipline: Chinese Materia Medica (Scientific Research of Guangxi Education Department [2022] No. 1), Innovation Project of Guangxi Graduate Education (YCSW2023381, JGY2022181).