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Letter to the Editor

Pharmacokinetics of idelalisib in chronic lymphocytic leukemia and follicular lymphoma disclose better outcomes for patients with lower exposure

Fabien Despasa Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Centre de Pharmacovigilance, de Pharmacoépidémiologie et d‘Informations sur le Médicament, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire de Toulouse, Toulouse, FranceORCID Iconhttps://orcid.org/0000-0002-3116-9963View further author information
ORCID Icon,
Maria Chaoukib Centre de Recherches en Cancérologie de Toulouse (CRCT), Université de Toulouse, Institut National de la Santé et de la Recherche Médicale (Inserm) U1037, Centre National de la Recherche Scientifique (CNRS) U5071, Toulouse, France;c TouCAN (Laboratoire d‘Excellence Toulouse Cancer), Toulouse, FranceView further author information
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Sandra de Barrosa Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Centre de Pharmacovigilance, de Pharmacoépidémiologie et d‘Informations sur le Médicament, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire de Toulouse, Toulouse, FranceView further author information
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Baptiste Bonneaua Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Centre de Pharmacovigilance, de Pharmacoépidémiologie et d‘Informations sur le Médicament, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire de Toulouse, Toulouse, FranceView further author information
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Ben Allalb Centre de Recherches en Cancérologie de Toulouse (CRCT), Université de Toulouse, Institut National de la Santé et de la Recherche Médicale (Inserm) U1037, Centre National de la Recherche Scientifique (CNRS) U5071, Toulouse, France;c TouCAN (Laboratoire d‘Excellence Toulouse Cancer), Toulouse, France;d Institut Claudius-Regaud, Institut Universitaire du Cancer de Toulouse (IUCT)-Oncopôle, Centre Hospitalier Universitare de Toulouse, Toulouse, FranceView further author information
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Julie Guillermet-Guibertb Centre de Recherches en Cancérologie de Toulouse (CRCT), Université de Toulouse, Institut National de la Santé et de la Recherche Médicale (Inserm) U1037, Centre National de la Recherche Scientifique (CNRS) U5071, Toulouse, France;c TouCAN (Laboratoire d‘Excellence Toulouse Cancer), Toulouse, FranceView further author information
&
Loïc Ysebaertb Centre de Recherches en Cancérologie de Toulouse (CRCT), Université de Toulouse, Institut National de la Santé et de la Recherche Médicale (Inserm) U1037, Centre National de la Recherche Scientifique (CNRS) U5071, Toulouse, France;c TouCAN (Laboratoire d‘Excellence Toulouse Cancer), Toulouse, France;e Service d‘Hématologie, Institut Universitaire du Cancer de Toulouse (IUCT)-Oncopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, FranceCorrespondence[email protected]
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Received 26 Sep 2023, Accepted 05 May 2024, Published online: 15 May 2024
 
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Acknowledgments

FD, SDB and LY performed the research. FD, SDB and LY designed the research study. BA, MC and JGG contributed essential reagents or tools. BB analyzed the data. FD, SDB and LY wrote the paper. Medical writing for this manuscript was assisted by MPIYP (MC Béné), Paris, France.

Disclosure statement

No potential competing interest was reported by the authors.

Additional information

Funding

This study was supported by the French National Drug Agency (ANSM), the French National Research Agency (ANR) (project CAPTOR PHUC-001) and TouCANANR Laboratory of Excellence, MSCA-ITN/ETN PIPgen (Project ID: 955534, salary for MC).
This work was funded by the Agence Nationale de la Recherche; Toucan ANR Laboratory of Excellence, MSCA-ITN/ETN PIPgen; Agence Nationale du Médicament et des produits de Santé (ANSM).

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