Targeting Nrf2 signaling pathway: new therapeutic strategy for cardiovascular diseases

Abstract

Cardiovascular diseases (CVDs) are the leading cause of death globally, with oxidative stress (OS) identified as a primary contributor to their onset and progression. Given the elevated incidence and mortality rates associated with CVDs, there is an imperative need to investigate novel therapeutic strategies. Nuclear factor erythroid 2-related factor 2 (Nrf2), ubiquitously expressed in the cardiovascular system, has emerged as a promising therapeutic target for CVDs due to its role in regulating OS and inflammation. This review aims to delve into the mechanisms and actions of the Nrf2 pathway, highlighting its potential in mitigating the pathogenesis of CVDs.

Keywords:

• Nuclear factor erythroid 2-related factor 2 (Nrf2)
• cardiovascular diseases (CVDs)
• oxidative stress (OS)
• therapeutic strategy
• Nrf2 activators

Author contributions

Conceptualisation, Qi Wu and Mengxiao Zhang; writing original draft, Qi Wu, Jiangting Yao, Mengyun Xiao, Xiawei Zhang, Xinting Xi; drawing illustrations, Qi Wu; writing-review & editing, Qi Wu and Mengxiao Zhang; supervision, Qi Wu and Mengxiao Zhang; funding acquisition, Qi Wu and Mengxiao Zhang. All authors have read and agreed to the published version of the manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the National Natural Science Foundation of China under Grant [No. 82304640]; National College Students Innovation and Entrepreneurship Training Program under Grant [No. 202310367012]; and National College Students Innovation and Entrepreneurship Training Program under Grant [No. 202210367044].