ABSTRACT
Background
The study aimed to investigate the association of IL-6 and IL-10 polymorphisms with susceptibility to glaucoma by analyzing all relevant individual studies.
Materials and Methods
Relevant articles were gathered from PubMed, Web of Science, Embase, WanFang, and CNKI databases up to 15 October 2023. Odds ratios (ORs) were used to evaluate the association strengths, along with 95% confidence intervals (CIs).
Results
Seven case-control studies involving 1408 cases and 1789 controls on the IL-6 -174 G>C polymorphism, and three studies with 675 cases and 1100 controls on the IL-6 -572 G>C were included. Moreover, three separate studies, each comprising 442 cases and 672 controls, investigated the IL-10 -592C>A, −819T>C, and −1082A>G polymorphisms. The combined data indicated a significant association between −592C>A, −819T>C, and −1082A>G at IL-10 gene and IL-6 -572 G>C with glaucoma susceptibility, with no correlation found for IL-6 -174 G>C.
Conclusions
The study found that IL-10 -592C>A, −819T>C, −1082A>G, and IL-6 -572 G>C polymorphisms were linked to glaucoma risk. However, no significant association was observed for IL-6 -174 G>C. These findings imply a possible connection between genetic variations in these genes and glaucoma risk. Further research is crucial to fully understand the underlying mechanisms and their significance in managing and preventing glaucoma.
Acknowledgments
The authors wish to express their gratitude to all contributors who supplied the foundational data.
Disclosure statement
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.
Author contributions
Conceptualization: Ahmadreza Golshan, Mohammad Bahrami
Data curation: Seyed Alireza Dastgheib, Hossein Neamatzadeh
Formal analysis: Hossein Neamatzadeh, Reyhaneh Mohsenzadeh-Yazdi
Investigation: Fatemeh Asadian, Maryam Aghasipour, Kamran Alijanpour
Methodology: Seyed Alireza Dastgheib, Maryam Aghasipour
Supervision: Ahmadreza Golshan, Mohammad Bahrami
Validation: Mohammad Manzourolhojeh, Seyed Alireza Dastgheib
Writing-original draft: Amirmasoud Shiri, Kazem Aghili, Sahel Khajehnoori
Writing-review, editing and Revision: Amirmasoud Shiri, Kamran Alijanpour
Data availability statement
The data supporting this study can be obtained from the corresponding author upon request.
Ethics approval
This is a meta-analysis and ethical approval is not required.