Association between NUDT17 polymorphisms and breast cancer risk

ABSTRACT

Background

Breast cancer (BC) is the leading cause of cancer death among women worldwide. The nudix hydrolase 17 (NUDT17) may play notable roles in cancer growth and metastasis. In this study, we explored the importance of NUDT17 gene polymorphism in patients with BC.

Methods

In our study, 563 BC patients and 552 healthy controls participated. We used logistic regression analysis to calculate odds ratios (OR) and 95% confidence intervals (CI), and multifactor dimension reduction (MDR) analysis of SNP-SNP interactions. Finally, UALCAN and THPA databases were used for bioinformatics analysis.

Results

The rs9286836 G allele was associated with a decreased the BC risk (p = 0.022), and the carriers of rs2004659 G allele had a 32% decreased risk of BC than individuals with allele A (p = 0.004). In the four genetic models, rs9286836 and rs2004659 reduced the risk of BC. Additionally, we found that the NUDT17 SNPs were associated with BC risk under age, tumor size, and clinical stage stratification. The MDR analysis showed that the five-locus interaction model was the best in the multi-locus model.

Conclusion

Our study found that NUDT17 single nucleotide polymorphisms are associated with BC susceptibility in Chinese Han population.

KEYWORDS:

• Breast cancer
• NUDT17
• Chinese Han population
• single nucleotide polymorphism
• correlation analysis

Abbreviations

BC: Breast cancer; ccRCC: Clear cell renal cell carcinoma; CI: Confidence interval; ER: Estrogen receptor; HWE: Hardy-Weinberg equilibrium; MAF: Minor allele frequencies; NUDT17: Nudix hydrolase 17; OR: Odds ratio; OS: Overall survival; PR: Progesterone receptor; TCGA: The Cancer Genome Atlas; WES: Whole-exome sequencing.

Consent to participate

The authors confirm that the informed consent of all subjects and/or their legal guardians has been obtained.

Consent for publication

Written informed consent was obtained from the patient for publication of this report.

Availability of data and material

All data obtained from the current study are available from the corresponding author upon reasonable request.

Authors’ contributions

Conceptualization was undertaken by JH Han; Methodology was undertaken by JH Han and TB Jin. Formal analysis and investigation were undertaken by M Zhang while original draft preparation was undertaken by J Liang and WQ Zhou. Finally, TB Jin undertook further review and editing. All authors have read and approved the manuscript.

Acknowledgments

We would like to thank all the patients and individuals in this study for their participation.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/14737159.2024.2353700.

Additional information

Funding

This manuscript was not funded.