Inhibition of oxidative stress of Biancaea sappan (L) Tod. from Java

Abstract

Increased reactive oxygen species and advanced glycation end products are often associated with human ageing and degenerative diseases. Biancaea sappan L serves as a medicinal plant and a healthy drinks ingredient in Java. However, the pharmacological investigation of the plant native to this island is still lacking in depth. In the current study, DNA barcoding using the marker gene maturase K (matK), evaluation of the chemical composition, total phenolic content (TPC) and antioxidant properties, antiglycation, anti-β-amyloid, anti-inflammatory, and selective cytotoxic activities were performed. B. sappan shares well-known phytoconstituents with other members of the genus Biancaea. The heartwood ethanol extract possesses the most prominent antioxidant, anti-inflammatory, and anti-β-amyloid effects. The aqueous extract demonstrated a most substantial anti-glycation activity and was rich in phenolics. The ethanol extract from heartwood exhibited the highest cytotoxicity against SW-48, indicating B. sappan heartwood from Java holds promise as antioxidants and may selectively inhibit colorectal cancer.

Graphical Abstract

Keywords:

• Caesalpinia
• brazilin
• antiglycation
• antioxidant
• anti-colorectal cancer

Disclosure statement

The authors declare that they have no competing interests. This manuscript has not been published elsewhere.

Data availability statement

The data used to support the findings of this study have been included in this article and in Supplementary Files. The matK sequence datasets generated and/or analysed during the current study are available in https://tinyurl.com/SeqCsappan.

Additional information

Funding

This research was funded by PT. Indofood Sukses Makmur Tbk through the Indofood Research Nugraha Programme 2021-2022 and the Atma Jaya Catholic University of Indonesia through Internal Research Grant 2021.