The role of inflammation markers in occurrence of radial artery occlusion

Abstract

Aim: Radial artery occlusion (RAO) is a major complication of catheterization via transradial access (TRA). Our aim is to reveal the ability of high-sensitive C-reactive protein (hs-CRP) and complete blood count (CBC) components, which are inflammation markers, to predict RAO. Methods: Patients were divided into two groups: 103 with RAO and 300 without RAO. The relationship between CRP, CBC components and RAO was evaluated. Results: A significant increase in hs-CRP, monocyte, platelet (PLT), platelet distribution width (PDW) and plateletcrit values was observed after TRA, and only the increase in PDW, PLT and hs-CRP was found to be independent determinants in regression analysis. Conclusion: High PDW and PLT and increased hs-CRP levels are new independent determinants of the development of RAO.

TWEETABLE ABSTRACT

The role of inflammation markers in occurrence of radial artery occlusion that restricts the transradial cardiac catheterization.

Summary points

• A significant increase in hs-CRP, monocyte, platelet (PLT), platelet distribution width (PDW) and plateletcrit values was observed after radial artery catheterization, and the increase in PDW, PLT and hs-CRP was found to be independent determinants only for radial artery occlusion (RAO).

• These data indicate that high baseline hs-CRP levels in patients with RA catheterization predict the risk of developing RAO in the future.

• It also supports the hypothesis that hs-CRP may serve as a molecular marker for RAO and that higher levels may be associated with greater disease extent.

• Our study indicated that PLT count could be useful marker for evaluation of thromboembolic diseases such as RAO.

Keywords: :

• complete blood count
• high sensitive C-reactive protein
• platelet
• platelet distribution width
• radial artery occlusion

Financial disclosure

The authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, stock ownership or options and expert testimony.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval (2019/71522473/050.01.04/161) and/or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations.

In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.