Expert Opinion on Drug Discovery, Volume 19, Issue 5 (2024)

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Expert Opinion on Drug Discovery, Volume 19, Issue 5 (2024)

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Editorial

Editorial
What is the plausibility that all drugs will be designed by computers by the end of the decade?
José L. Medina-Franco & Edgar López-López
Pages: 507-510
Published online: 19 Mar 2024
First Page PreviewforWhat is the plausibility that all drugs will be designed by computers by the end of the decade? | Full Text | References | PDF (1.2 MB) | EPUB
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Drug Discovery Case History

Article
The preclinical discovery and clinical evaluation of tirzepatide for the treatment of type 2 diabetes
Ioannis Avgerinos, Panagiota Kakotrichi, Thomas Karagiannis, Eleni Bekiari & Apostolos Tsapas
Pages: 511-522
Published online: 05 Mar 2024
AbstractforThe preclinical discovery and clinical evaluation of tirzepatide for the treatment of type 2 diabetes | Full Text | References | PDF (309.5 KB) | EPUB
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Perspective

Comment
Using automated patch clamp electrophysiology platforms in ion channel drug discovery: an industry perspective
Marc Rogers, Alison Obergrussberger, Artem Kondratskyi & Niels Fertig
Pages: 523-535
Published online: 13 Mar 2024
AbstractforUsing automated patch clamp electrophysiology platforms in ion channel drug discovery: an industry perspective | Full Text | References | PDF (1.1 MB) | EPUB
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Review

Review Article
Treatment of highly virulent mammarenavirus infections—status quo and future directions
Ivette A. Nuñez, Anya Crane, Ian Crozier, Gabriella Worwa & Jens H. Kuhn
Pages: 537-551
Published online: 12 Apr 2024
AbstractforTreatment of highly virulent mammarenavirus infections—status quo and future directions | Full Text | References | PDF (1.1 MB) | EPUB
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Review Article
Stroke genetics and how it Informs novel drug discovery
Julija Valančienė, Kazimieras Melaika, Aleksandra Šliachtenko, Kamilė Šiaurytė-Jurgelėnė, Aleksandra Ekkert & Dalius Jatužis
Pages: 553-564
Published online: 04 Mar 2024
AbstractforStroke genetics and how it Informs novel drug discovery | Full Text | References | PDF (346.7 KB) | EPUB
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Review Article
C. elegans: a prominent platform for modeling and drug screening in neurological disorders
Stefano Romussi, Sebastián Giunti, Natalia Andersen & María José De Rosa
Pages: 565-585
Published online: 20 Mar 2024
AbstractforC. elegans: a prominent platform for modeling and drug screening in neurological disorders | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
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Review Article
Potential Alzheimer’s disease drug targets identified through microglial biology research
Izabela Lepiarz-Raba, Taufik Hidayat, Anthony J. Hannan & Ali Jawaid
Pages: 587-602
Published online: 08 Apr 2024
AbstractforPotential Alzheimer’s disease drug targets identified through microglial biology research | Full Text | References | PDF (3.5 MB) | EPUB
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Review Article
Identification of the abnormalities in astrocytic functions as potential drug targets for neurodegenerative disease
Valtteri Syvänen, Jari Koistinaho & Šárka Lehtonen
Pages: 603-616
Published online: 26 Feb 2024
AbstractforIdentification of the abnormalities in astrocytic functions as potential drug targets for neurodegenerative disease | Full Text | References | PDF (2.2 MB) | EPUB
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Review Article
Omega-3 polyunsaturated fatty acid derived lipid mediators: a comprehensive update on their application in anti-cancer drug discovery
Michael Murray
Pages: 617-629
Published online: 09 Apr 2024
AbstractforOmega-3 polyunsaturated fatty acid derived lipid mediators: a comprehensive update on their application in anti-cancer drug discovery | Full Text | References | PDF (925.7 KB) | EPUB
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