Antiprotozoal Activity of Sesquiterpenes from Jasonia Glutinosa

L. Villaescusa-Castillo 1Laboratory of Pharmacognosy, Faculty of Pharmacy, University of Alcala de Henares, Madrid, Spain

A.M. Díaz-Lanza 1Laboratory of Pharmacognosy, Faculty of Pharmacy, University of Alcala de Henares, Madrid, Spain

M. Gasquet 2Laboratory of Parasitology, Faculty of Pharmacy, University d Aix Marseille, Marseille, France

F. Delmas 2Laboratory of Parasitology, Faculty of Pharmacy, University d Aix Marseille, Marseille, France

E. Ollivier 3Laboratory of Pharmacognosy, Faculty of Pharmacy, University dAix Marseille, Marseille, France

M. Bernabé 4Institute of Organic Chemistry, C.S.I.C. C/Juan de la Cierva, Madrid

R. Faure 5URA 1411, University d Aix Marseille III, Marseille, France

R. Elias 1Laboratory of Pharmacognosy, Faculty of Pharmacy, University of Alcala de Henares, Madrid, Spain

G. Balansard 1Laboratory of Pharmacognosy, Faculty of Pharmacy, University of Alcala de Henares, Madrid, Spain

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Abstract

Two sesquiterpene alcohols, [11 R]-eudesm-4(14)-en-5ß,11,12-triol ( 1 ) and [11R]-eudesm-4(14)-en-5a,11-12-triol ( 2 ), from Jasonia glutinosa aerial parts (Asteraceae), have been tested using an in vitro technique against Leishmania donovani (promastigote forms) and Plasmodium falciparum . Sesquiterpene 1 was not effective at the assayed concentrations. Sesquiterpene 2 was found to be active against Leishmania donovani and Plasmodium falciparum .

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Antiprotozoal Activity of Sesquiterpenes from Jasonia Glutinosa

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Antiprotozoal Activity of Sesquiterpenes from Jasonia Glutinosa

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