Inhibition of Gastric Acid Secretion by Bunodosoma cavernata Extract

Abstract

The saline extract of Bunodosoma cavernata (6.0 µg protein/100 g body wt i.v.) did not affect basal acid secretion in rats. The extract, however, completely blocked the induced-release of gastric acid by histamine (0.2 mg/100 g body wt i.v.) and pentagastrin (0.6 µg/kg body wt i.v.). These effects were produced when the extract was administered 50 min before the drugs. Also, the extract abolished the stimulant action of both histamine and pentagastrin when it was administered 50 min before application of the drugs. However, the extract failed to influence the basal acid output.