Effect of Thapsia Essential Oils on Bile Composition in Rats

Pinarosa Avato 1Dipartimento Farmaco Chimico, Universita, Via E. Orabona 4, I 70125 Bari, Italy

Caterina De Ruvo 1Dipartimento Farmaco Chimico, Universita, Via E. Orabona 4, I 70125 Bari, Italy

Saverio Cellamare 1Dipartimento Farmaco Chimico, Universita, Via E. Orabona 4, I 70125 Bari, Italy

Angelo Carotti 1Dipartimento Farmaco Chimico, Universita, Via E. Orabona 4, I 70125 Bari, Italy

Michele Mazzoccoli 2Instituto di Farmacologia, Universita, Piazza G. Cesare, I 70124 Bari, Italy

Giovanni Siro-Brigiani 2Instituto di Farmacologia, Universita, Piazza G. Cesare, I 70124 Bari, Italy

Abstract

The effect on rat bile composition of the essential oils from the fruits of three different chemotypes of Thapsia has been studied. For comparison, the major components of Thapsia essential oils, limonene, geranylacetate and methyleugenol, as well as menthol and peppermint oil, were also included in the investigation. Data obtained show that the tested drugs enhance bile secretion by increasing bile acid-independent flow (BAIF). Biotransformation products of the tested drugs were detected in bile samples.

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Effect of Thapsia Essential Oils on Bile Composition in Rats

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Effect of Thapsia Essential Oils on Bile Composition in Rats

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