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Abstract
The chemopreventive properties of a Spirulina fusiformis (blue green algae) suspension in olive oil on 7,12-dimethylbenz(a)anthracene (DMBA) induced skin papillomagenesis in female Swiss albino mice are being reported. A significant reduction in the values of tumor incidence, tumor burden and cumulative number of papillomas was observed in mice treated orally with Spirulina fusiformis suspension continuously at pre-, peri- and post-initiation stages of papillomagenesis as compared to the control group. Treatment of Spirulina fusiformis suspension by oral gavage for 15 days resulted in a significant decrease in the cytochrome P-450 content of the liver (p < 0.01). Conversely, glutathione S-transferase activity was observed to be significantly elevated as compared with the control group (p < 0.1) following treatment with Spirulina fusiformis suspension.