Biological Activity of Crude Extract and Saponin Pseudoginsenoside-RT1 Derived from the Fruit of Randia siamensis

Chaweewan Jansakul Faculty of Science, Prince of Songkla University, Hat Yai, Thailand

Kanokkan Intarit Faculty of Science, Prince of Songkla University, Hat Yai, Thailand

Arunporn Itharat Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Thailand

Thatree Phadungcharoen Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

Nijsiri Ruangrungsi Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

Alexandru Merica Guelph–Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry and Biochemistry, University of Guelph, Guelph, Ontario, Canada

Gordon L. Lange Guelph–Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry and Biochemistry, University of Guelph, Guelph, Ontario, Canada

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Abstract

Ursolic acid (1), pseudoginsenoside-RP 1 (2), and pseudoginsenoside-RT 1 (3) were isolated from the fruit of Randia siamensis. 13 C NMR spectroscopy was particularly useful in confirming the structures of these components. Studies with rats showed that saponin 3 caused a decrease in blood pressure, an increase in heart rate and an increase in spontaneous contractility of the uterus. Also, a crude ethanol extract of the fruit of R. siamensis exhibited acute ichthyotoxic activity.

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Biological Activity of Crude Extract and Saponin Pseudoginsenoside-RT1 Derived from the Fruit of Randia siamensis

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Biological Activity of Crude Extract and Saponin Pseudoginsenoside-RT1 Derived from the Fruit of Randia siamensis

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