Cytotoxic Activity of Some Indole Derivatives and Indole Metabolites of Streptomyces staurosporeus

Shu-Wei Yang Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA

Geoffrey A. Cordell Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA

Hee-Byung Chai Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA

Mei-Shiang Jang Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA

John M. Pezzuto Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA

Abstract

The cytotoxic potential and structure activity relationships of several indole metabolites obtained from feeding experiments using Streptomyces staurosporeus, a staurosporine producer, are described. 6-Fluoro-tryptamine and N b -acetyl-tryptamine-5- O -a-L-rhamnopyranoside, a metabolite obtained from the feeding experiment, demonstrated greatest activity with KB cells in culture, by means of an unknown mechanism.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Cytotoxic Activity of Some Indole Derivatives and Indole Metabolites of Streptomyces staurosporeus

Information for

Open access

Opportunities

Help and information

Cytotoxic Activity of Some Indole Derivatives and Indole Metabolites of Streptomyces staurosporeus

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature