Polyphenolic Compounds of Sideritis lycia and Their Anti-Inflammatory Activity

Abstract

Four phenylpropanoid glycosides lavandulifolioside 1, martynoside 2, verbascoside (=acteoside) 3 and leucosceptoside A 4, were isolated from aerial parts of Sideritis lycia Boiss. et Heldr. (Lamiaceae). Their structures were determined by chromatographic and spectroscopic methods (UV, IR, 1 H-NMR, 13 C-NMR, FAB-MS). These compounds and flavonoid glycosides isolated from the same plant in our previously study were screened for their anti-inflammatory activity using the carrageenan-induced mouse paw edema test. The active compounds were then investigated for their effect on gastric ulceration. Although flavonoid glycosides showed higher activity than the phenylpropanoid glycosides, the gastric ulceration effect of phenylpropanoid glycosides was less than flavonoid glycosides.