Stereoselective Hydroxylation of (+)-dihydroperfamine Cunninghamella echinulata

Abdel-Rahim S. Ibrahim Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Mohamed S. Ahmed Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Mohammed A. Al-Yahya Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Farouk S. El-Feraly Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Abstract

The alkaloid (+)-dihydroperfamine (1) was stereoselectively hydroxylated in 47% yield at the 5" position, using the fungus Cunninghamella echinulata. The structure and stereochemistry of metabolite 2 have been confirmed by 1D and 2D NMR spectroscopy, including a NOESY experiment. The hydroxylation pattern of 2 is similar to that found in the alkaloid haplatine (3).

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Stereoselective Hydroxylation of (+)-dihydroperfamine Cunninghamella echinulata

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Stereoselective Hydroxylation of (+)-dihydroperfamine Cunninghamella echinulata

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