Sesquiterpene Lactones from Ambrosia artemisiaefolia (Asteraceae)

Juceni P. David Faculdade de Farmacia,

Alessandro J. de O. Santos Faculdade de Farmacia,

Maria L. da S. Guedes Instituto de Biologia

Jorge M. David Instituto de Quimica, Universidade Federal da Bahia, Salvador, Bahia, Brazil

Hee-Byung Chai Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA

John M. Pezzuto Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA

Cindy K. Angerhofer Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA

Geoffrey A. Cordell Faculdade de Farmacia,

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Abstract

Paulitin and isopaulitin were isolated from Ambrosia artemisiaefolia and evaluated for their cytotoxic and antimalarial activities. The relative configuration of dumosin was also established.

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Sesquiterpene Lactones from Ambrosia artemisiaefolia (Asteraceae)

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Sesquiterpene Lactones from Ambrosia artemisiaefolia (Asteraceae)

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