Pharmacological Studies of Mentha longifolia Phenolic Extracts. II. Hepatoprotective Activity

Neda Mimica-Dukic Institute of Chemistry, Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Trg Dositeja Obradovica 3, Yugoslavia

Mira Popovic Institute of Chemistry, Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Trg Dositeja Obradovica 3, Yugoslavia

Vida Jakovljevic Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmocology, University of Novi Sad, 21000 Novi Sad, Yugoslavia

Anna Szabo Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmocology, University of Novi Sad, 21000 Novi Sad, Yugoslavia

Olga Gašic Institute of Chemistry, Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Trg Dositeja Obradovica 3, Yugoslavia

Abstract

The effects of Mentha longifolia crude ethanolic extract (F 1), rich in luteolin glycosides (F 2), apigenin glycosides (F 3) and phenolic acids (F 4), were studied on CCl 4 -induced liver injury in mice. Administration of CCl 4 -induced significant impairment in hepatic antioxidant status, decreasing the glutathione content and superoxide dismutase activity, and stimulating lipid peroxidation. Pretreatment with Mentha longifolia extracts significantly improved hepatic antioxidant status in mice, which was most pronounced in the reduction of CCl 4 -mediated lipid peroxidation. In addition, in pretreated animals, an increase in hepatic glutathione and superoxide dismutase activity, as well as a decrease of cytochrome P450, was found.

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Pharmacological Studies of Mentha longifolia Phenolic Extracts. II. Hepatoprotective Activity

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