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Research Article

Anti-Diarrhegenic and Anti-Ulcer Properties of Irvingia gabonensis in Rats

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Pages 340-345 | Published online: 29 Sep 2008
 

Abstract

The crude methanol extract of Irvingia gabonensis was evaluated for effects on gastrointestinal motility and indomethacin-induced gastric ulceration. The extract (50, 100 and 200 mg/kg, p.o.) exhibited dose-dependent inhibition of indomethacin-induced gastric ulceration that seems to be stronger than cimetidine (50 mg/kg). A significant decrease in gastric acid secretion with concomitant increase in intragastric mucous secretion was produced by the extract at all doses studied. Gastrointestinal motility was significantly reduced in the extract-treated rats. Acute toxicity studies showed there were no deaths either 24 h or 7 days after the application of the extract up to 1600 mg/kg. The results show that Irvingia gabonensis possesses anti-diarrhegenic and anti-ulcer properties. The anti-ulcer property probably act via a reduction in gastric acid secretion and an increase in the intragastric mucous secretion.

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