Effect of Methoxsalen and an Infusion of Silybum marianum on Enzymes Relevant to Liver Function

Aleksandar Raskovic Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine; Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Novi Sad, Yugoslavia

Vida Jakovljevic Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine; Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Novi Sad, Yugoslavia

Mira Popovic Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine; Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Novi Sad, Yugoslavia

Ana Sabo Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine; Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Novi Sad, Yugoslavia

Olivera Piljevic Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine; Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Novi Sad, Yugoslavia

Abstract

The effect of an infusion of Silybum marianum on some enzymes relevant to liver function was investigated in mice. Methoxsalen was administered in doses of 2.5 and 5.0 mg/kg (i.p.) 4 h prior to decapitation. The infusion of Silybum marianum was administered (p.o.) 24 and 2 h before methoxsalen, while the third dose was given together with methoxsalen. The animals were sacrificed 4 h later. The results showed that the content of glutathione, cytochrome P450 and transaminase in animal tissues suggests the hepatoprotective action of Silybum marianum infusion.

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Effect of Methoxsalen and an Infusion of Silybum marianum on Enzymes Relevant to Liver Function

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Effect of Methoxsalen and an Infusion of Silybum marianum on Enzymes Relevant to Liver Function

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