Anticonvulsant and GABA Uptake Inhibition Properties of Venom Fractions from the Spiders Parawixia bistriata and Scaptocosa raptoria

M.A.R. Cairrão Universidade de Sao Paulo, Laboratorio de Neurobiologia e Peconhas, Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo;

A.M. Ribeiro Universidade de Sao Paulo, Laboratorio de Neurobiologia e Peconhas, Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo;

A.B. Pizzo Universidade de Sao Paulo, Laboratorio de Neurobiologia e Peconhas, Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo;

A.C.K. Fontana Laboratorio de Neuroquimica, Departamento de Bioquimica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo.

R.O. Beleboni Laboratorio de Neuroquimica, Departamento de Bioquimica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo.

J. Coutinho-Netto Laboratorio de Neuroquimica, Departamento de Bioquimica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo.

A. Miranda Departamento de Biofisica, Universidade Federal de Sao Paulo

W.F. Santos Universidade de Sao Paulo, Laboratorio de Neurobiologia e Peconhas, Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo;

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Abstract

In this article we describe an in vivo anticonvulsant effect from denatured crude venom and partially isolated fractions from two spiders: Parawixia bistriata and Scaptocosa raptoria. Intracerebroventricular injections of these venoms and fractions abolished rat convulsive tonic-clonic seizures induced by picrotoxin, bicuculline and pentylenetetrazole, and also, inhibited GABA uptake in synaptosomes of rat cerebral cortex. The venoms described in this work seems to be promising tools for the study of the GABAergic system, and may be a potential source for new anticonvulsant drugs.

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Anticonvulsant and GABA Uptake Inhibition Properties of Venom Fractions from the Spiders Parawixia bistriata and Scaptocosa raptoria

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Anticonvulsant and GABA Uptake Inhibition Properties of Venom Fractions from the Spiders Parawixia bistriata and Scaptocosa raptoria

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