Antifungal Activity of Secondary Metabolites of Centaurea raphanina ssp. mixta, Growing Wild in Greece

Constantinos Panagouleas Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Greece;

Helen Skaltsa Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Greece;

Diamanto Lazari Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Greece;

Alexios-Leandros Skaltsounis Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Greece;

Marina Sokovic Department of Plant Physiology, Mycological Laboratory, Institute for Biological Research, Belgrade, Yugoslavia

Abstract

The present study was carried out on the aerial parts of C. raphanina Sm. ssp. mixta (DC.) Runemark (Asteraceae), which is a commonly edible plant in Greece, on maturation stage. Although the isolation procedure is the appropriate one for the isolation of sesquiterpene lactones, the analysis revealed the presence of only one sesquiterpene lactone, namely cnicin, in small amounts. The main compounds were found to belong to polyphenols. The in vitro antifungal activity of the isolated compounds was tested, using the micro-dilution method. Only cnicin has been proved to be active against all fungi tested with a fungicidal potential higher than miconazole.

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Antifungal Activity of Secondary Metabolites of Centaurea raphanina ssp. mixta, Growing Wild in Greece

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Antifungal Activity of Secondary Metabolites of Centaurea raphanina ssp. mixta, Growing Wild in Greece

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