Reconstruction of mastoid cortex defect using bone morphogenetic protein: an experimental study in the guinea pig

Abstract

Objective The aim of this experimental study was to examine whether recombinant human bone morphogenetic protein-2 (rhBMP-2) could induce new bone formation in a small hole drilled through the temporal bone near the external auditory canal wall in guinea pigs.

Material and Methods A 4-mm diameter hole was made in the center of the temporal bone and a piece of collagen sheet infiltrated with rhBMP-2 was placed in the hole. New bone formation was confirmed by means of X-ray examination and the bone mineral density was quantified using dual-energy X-ray absorptiometry 1, 2 and 4 weeks after treatment.

Results The bone mineral density in the rhBMP-2-treated group was significantly increased compared to the control group.

Conclusion These results suggest that rhBMP-2 induces remarkable new bone formation in the temporal bone and will be useful in clinical ear surgery.

• new bone formation
• recombinant human bone morphogenetic protein-2
• temporal bone
• X-ray absorptiometry

Sugimoto A, Hakuba N, Gyo K. Reconstruction of mastoid cortex defect using bone morphogenetic protein: an experimental study in the guinea pig. Acta Otolaryngol 2004; 124: 253–257.

Sugimoto A, Hakuba N, Gyo K. Reconstruction of mastoid cortex defect using bone morphogenetic protein: an experimental study in the guinea pig. Acta Otolaryngol 2004; 124: 253–257.