Expression of Notch1 and Hes5 in the developing olfactory epithelium

Yorihisa Orita Departments of Otolaryngology-Head and Neck Surgery, Okayama School of Medicine and Dentistry, Okayama, JapanCorrespondence[email protected]

, MD,

Hitoshi Nagatsuka Oral Pathology Medicine, Okayama School of Medicine and Dentistry, Okayama, Japan

Hidetsugu Tsujigiwa Oral Pathology Medicine, Okayama School of Medicine and Dentistry, Okayama, Japan

Junko Yoshinobu Departments of Otolaryngology-Head and Neck Surgery, Okayama School of Medicine and Dentistry, Okayama, Japan

Yukihide Maeda Departments of Otolaryngology-Head and Neck Surgery, Okayama School of Medicine and Dentistry, Okayama, Japan

Masashi Kakiuchi Departments of Otolaryngology-Head and Neck Surgery, Okayama School of Medicine and Dentistry, Okayama, Japan

Saeko Orita Departments of Otolaryngology-Head and Neck Surgery, Okayama School of Medicine and Dentistry, Okayama, Japan

Ayako Takeuchi Departments of Otolaryngology-Head and Neck Surgery, Okayama School of Medicine and Dentistry, Okayama, Japan

Yasushi Takeda Departments of Otolaryngology-Head and Neck Surgery, Okayama School of Medicine and Dentistry, Okayama, Japan

Kunihiro Fukushima Departments of Otolaryngology-Head and Neck Surgery, Okayama School of Medicine and Dentistry, Okayama, Japan

Noriyuki Nagai Oral Pathology Medicine, Okayama School of Medicine and Dentistry, Okayama, Japan

Kazunori Nishizaki Departments of Otolaryngology-Head and Neck Surgery, Okayama School of Medicine and Dentistry, Okayama, Japan

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Abstract

Conclusion. Notch signaling pathway may play an important role in the development of the olfactory epithelium (OE). Objectives. To elucidate whether the Notch signaling pathway mediates the developmental processes in the developing OE. Materials and methods. The expression of Notch1 and Hes5 in the developing OE of mice with ages ranging from embryonic day (E) 11 to postnatal day (PN) 14 was examined. Results. As detected by in situ hybridization, Notch1 was expressed in scattered cells located in the basal portion of the embryonic OE and later in the cell layer adjacent to the basal lamina from E11 to PN14. Hes5 was expressed in scattered cells located in the basal portion of the embryonic OE from E11. However, at the late embryonic stage, the number of Hes5-positive cells decreased and after birth distinct Hes5-positive cells were not observed in the OE.

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Expression of Notch1 and Hes5 in the developing olfactory epithelium

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Expression of Notch1 and Hes5 in the developing olfactory epithelium

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