Abstract
Objectives: Extramedullary plasmacytoma in the sinonasal tract or nasopharynx is rare. The aim of the study was to review data on symptoms, clinical findings, treatment and follow-up of plasmacytomas in the sinonasal and nasopharyngeal regions in order to delineate the main clinical characteristics and the optimal management.
Method: Twenty-five patients with sinonasal or nasopharyngeal plasmacytoma, diagnosed and treated at the Helsinki University Hospital during a 39-year period from 1975 to 2013 were retrospectively reviewed.
Results: There were 18 males and 7 females with a median age of 66 years (range, 36–80). Sixty-eight percent received only radiotherapy or (chemo)radiotherapy. Forty-seven percent of them had a complete response to primary radiotherapy and one patient had a complete response after receiving additional brachytherapy. Four patients were treated primarily with surgery only. Two of them had a local recurrence, but were then successfully treated with radiotherapy. Altogether, four patients received a combination of surgery and (chemo)radiotherapy. Forty-four percent were alive with no evidence of disease after a median follow-up time of 78 months. Forty percent died of their disease and 16% died of other causes.
Conclusions: Our study supports radiotherapy as a treatment of choice, but for small tumours surgery alone or in combination with radiotherapy may also be considered.
Chinese abstract
目的:鼻窦或鼻咽的髓外浆细胞瘤是罕见的。本研究的目的是审查鼻窦和鼻咽区血浆细胞瘤的症状、临床表现、治疗和随访情况, 以描写其主要临床特征和最佳治疗方案。
方法:回顾性重审了1975年至2013年39年间赫尔辛基大学医院诊断和治疗的25例鼻窦或鼻咽浆细胞瘤患者。
结果:这些患者中男性18例, 女性7例, 平均年龄为66岁(范围36-80岁)。百分之八十八只接受放射治疗或(化疗)放疗。 47%的患者对原发性放射疗法有完整的反应, 一名患者在接受额外的近距离放射治疗后有完整的反应。 4例患者主要仅用手术治疗。其中两例局部复发, 随后成功接受了放疗。总共有4名患者接受了手术和(化疗)放疗的联合治疗。中位随访时间78个月后, 百分之四十四的人活着, 没有显示任何疾病证据。百分之四十死于疾病, 百分之十六死于其它原因。
结论:我们的研究支持放疗作为可选治疗方法。但对于小肿瘤, 单独使用手术或与放射治疗组合也可考虑。
Disclosure statement
No conflict of interest to declare.