Correlation between subjective and objective measures in bilateral vestibulopathy

Abstract

Background

Bilateral vestibulopathy (BVP) is a chronic and potentially very disabling condition. The impact of the vestibular loss on quality of life (QoL) is variable and still up for discussion. However, previous studies have reported that BVP has a negative impact of QoL.

Aims/Objectives

The aim of the study was to evaluate the association between vestibulo-ocular reflex (VOR) gain and saccade pattern and patient reported QoL.

Materials and methods

Ten patients fulfilling the Bárány criteria of BVP were included in the study. All patients underwent vestibular evaluation using Head Impulse Paradigm (HIMP) and Suppression Head Impulse Paradigm (SHIMP) and responded to Dizziness Handicap Inventory (DHI). DHI was used as a measurement for QoL.

Results

Linear regression revealed a tendency to a correlation between lateral VOR-gain measured by HIMP or SHIMP and total DHI score. Covert saccades were related to low total DHI scores. No association was found between type of SHIMP saccade and QoL. No significant correlations were found.

Conclusion and significance

A tendency was found towards a relationship between lateral VOR-gain by HIMP or SHIMP and total DHI score. The study also indicates that covert saccades are related to low impact on QoL.

Chinese Abstract

背景：双侧前庭病 (BVP) 是一种慢性且可能高度致残的疾病。前庭丧失对生活质量 (QoL) 的影响是多样的, 仍有待讨论。然而, 根据以前的研究, BVP 对 生活质量 有负面影响。

目的：评估前庭-眼反射（VOR）增益及扫视模式和患者报告的生活质量之间的关联。

材料和方法：本研究纳入了 10 名符合BVP Barany标准的患者。所有患者均使用头冲范式(HIMP) 和 抑制头冲范式 (SHIMP) 进行前庭评估并回应头晕障碍量表 (DHI)。DHI用作生活质量的衡量标准。

结果：线性回归分析揭示了通过HIMP 或 SHIMP测得的横向 VOR 增益和 DHI 总分之间存有相关性的趋势。隐蔽扫视与 DHI 总分低有关。在 SHIMP 扫视类型和 生活质量 之间没有发现关联。没有发现显著的相关性。

结论和意义：我们发现, 通过 HIMP 或 SHIMP测得的横向 VOR 增益和 DHI 总分之间有相关的趋势。本研究还表明, 隐蔽扫视与低生活质量影响相关。

Keywords:

• Bilateral vestibulopathy
• DHI
• quality of life
• questionnaires
• vestibular hypofunction
• vestibulo-ocular reflex

Acknowledgments

The study has received no funding.

Disclosure statement

No potential conflict of interest was reported by the author(s).