Abstract
Background
Markers of tumorigenesis are essential factors which may play a major role in the early detection of head and neck carcinoma.
Aims/objectives
To assess concentration of HIF-1, GLUT1 and VEGF in tissue samples and blood serum and its correlation to the tumour size, nodal disease, pathologic differentiation and patients’ data.
Material and methods
Fifty-two patients diagnosed with laryngeal carcinoma stage I-IV in which concentration of HIF-1, GLUT1 and VEGF was assessed in tissue samples and blood serum using immunoassay method.
Results
HIF-1α, GLUT1, VEGF concentration was significantly higher in cancer tissue samples than in normal tissue (p < .001) and benign laryngeal lesions. Serum levels of the factors were significantly lower in the control group. Statistically significant difference regarding tumour size was found between T2 and T4 stages in HIF-1α concentration in cancer samples and serum.
Conclusions
The results show that high concentration of HIF-1α, GLUT1 and VEGF might be suggestive of carcinogenic process when diagnosing patients with laryngeal lesions and could promote early detection of malignancy.
Significance
The results of this study show importance of biochemical assessment in malignant tumours which may affect clinical decisions.
Chinese Abstract
背景:肿瘤发生的标志物是一个重要因素, 可能在头颈癌早期检测中起主要作用。
目的:评估组织样本和血清中 HIF-1、GLUT1 和 VEGF 的浓度及其与肿瘤大小、淋巴结疾病、病理分化和患者资料的关系。
材料与方法:52 例诊断为 I-IV 期喉癌的患者, 使用免疫测定法评估他们的组织样本和血清中 HIF-1、GLUT1 和 VEGF 的浓度。
结果:癌组织样本中的 HIF-1a、GLUT1、VEGF 浓度显著高于正常组织 (p < .001) 和良性喉病变。对照组血清因子水平显著较低。在 T2 和 T4 阶段的癌症样本和血清中 HIF-1a 浓度之间发现肿瘤大小有统计上的显著差异。
结论:结果表明, 高浓度的HIF-1a、GLUT1和VEGF可能提示喉部病变患者的致癌过程, 有助于早期发现恶性肿瘤。
意义:本研究结果显示了生化评估对恶性肿瘤的重要性, 这种评估可能影响临床决策。
Disclosure statement
The authors declare no financial or personal relationships with other people or organizations that could inappropriately influence this study. All authors have approved the final article.