https://orcid.org/0000-0003-4353-8989
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Abstract
Background
Delayed endolymphatic hydrops (DEH) is an inner ear disease that causes recurrent vertigo in the ipsilateral ear or fluctuating hearing in the contralateral ear due to endolymphatic hydrops secondary to preceding deafness. There are few reports of large, multicentre studies investigating the clinical-epidemiological characteristics of DEH.
Objective
This study aimed to clarify the characteristics of DEH in Japan.
Methods
Clinical data on 662 patients with DEH were analysed by nationwide, multicentre surveys conducted by the Peripheral Vestibular Disorders Research Group of Japan.
Results
The proportion of ipsilateral DEH (IDEH) was slightly higher than that of contralateral DEH (CDEH) at 55.4%. The time delay between onset of precedent deafness and onset of DEH was significantly longer for CDEH than for IDEH. The most common cause of precedent deafness was a disease of unknown cause with onset in early childhood (33.1%). Epidemiological characteristics were not significantly different between CDEH with and without vertigo.
Conclusion
DEH appearing to be caused by viral labyrinthitis has a high rate of onset within 40 years of precedent deafness. Clinical and epidemiological characteristics of IDEH, CDEH with vertigo, and CDEH without vertigo were very similar.
Significance
The clinical-epidemiological characteristics of DEH in Japan were clarified.
Chinese Abstract
背景：迟发性内淋巴水肿 (DEH) 是一种内耳疾病, 导致由内淋巴水肿引起的同侧耳复发性眩晕或继发于先例性耳聋的对侧耳听力波动。调查DEH的临床流行病学特征的大型多中心研究寥寥数几。
目的：本研究旨在阐明日本DEH的特点。
方法：通过由日本外周前庭疾病研究组进行的全国多中心调查来分析 662 例 DEH 患者的临床资料。
结果：同侧DEH（IDEH）比例为 57.5%, 略高于对侧DEH(CDEH)。先例性耳聋发作和 DEH 发作之间的时间延迟, CDEH明显长于 IDEH。先例性耳聋的最常见原因是一种儿童早期发病原因不明的疾病（33.2%）。伴有和不伴有眩晕的 CDEH 的流行病学特征没有显著差异。
结论：看似由病毒性迷路炎引起的DEH在先例性耳聋的40年内发病率较高。 IDEH、伴眩晕的CDEH以及无眩晕的 CDEH的临床和流行病学特征非常相似。
意义：厘清了日本DEH的临床流行病学特征。
Acknowledgements
We express our sincere appreciation for the assistance and cooperation of all members of the Department of Otolaryngology at the University of Toyama.
Disclosure statement
No potential conflict of interest was reported by the author(s).