Mucin receptors in chronic rhinosinusitis with nasal polyps

Abstract

Background

Nasal polyps (NPs) are non-neoplastic, painless inflammatory lesions of the sino-nasal mucosa. Nasal polyp physiopathology is not yet fully understood. There are many potential etiologies of NP, including chronic infections, allergies, asthma, aspirin sensitivity, anatomical disorders, and genetic causes.

Objective

The purpose of our study was to immunohistochemically demonstrate the presence of mucin (MUC) receptors in chronic rhinosinusitis (CRS) with nasal polyps and determine the relationships between the presence of these receptors and clinical findings.

Material and Methods

A total of 59 patients who underwent functional endoscopic sinus surgery due to CRS with NPs were included in the study. Groups with positive and negative MUC receptors were evaluated according to their clinical characteristics.

Results

According to the data we have obtained, surgery site quality and low-dose steroid response worsened with MUC5A receptor positivity and there were no significant relationships between MUC1 receptor positivity and clinical findings.

Conclusion

According to our results, MUC5A receptor positivity was associated with impaired surgical site quality and a reduced response to low-dose systemic steroids by NPs.

Chinese Abstract

背景：鼻息肉（NP）是鼻腔粘膜的非肿瘤性无痛性炎症性病变。鼻息肉的病理生理学尚不完全清楚。有许多潜在的病因包括慢性感染、过敏、哮喘、阿司匹林敏感、解剖障碍和遗传因素。

目的：我们研究的目的是用免疫组织化学方法证明这些粘蛋白受体在伴有鼻息肉的慢性鼻窦炎 (CRS)的存在, 并确定它们的存在与临床发现之间的关系。

材料和方法：共59例因伴有鼻息肉的慢性鼻窦炎而接受功能性内窥镜鼻窦手术的患者被纳入研究。MUC受体阳性和阴性的组群根据其临床特征接受了评估。

结果：根据我们获得的数据, 手术部位质量和低剂量类固醇反应随着MUC5A受体阳性而恶化, 并且MUC1受体阳性和临床发现之间没有显著关系。

结论：根据我们的结果, MUC5A受体阳性与受损的手术部位质量以及NPs对低剂量全身类固醇的反应降低相关。

Keywords:

• Nasal polyp
• chronic sinusitis
• mucin receptors

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was support of the Scientific Research Projects Coordinatorship of the University of Health Sciences [Project No: 2019/007].