Efficacy of intravenous magnesium sulfate infusion on postoperative pain and quality of recovery for septorhinoplasty: a randomized controlled study

Abstract

Background

The pain that occurs after septorhinoplasty is an important factor affecting the comfort of the patient.

Objectives

To investigate the effect of perioperative intravenous magnesium sulfate infusion on postoperative pain and quality of recovery in patients underwent septorhinoplasty surgery.

Material and methods

One hundred twenty patients who underwent septorhinoplasty were randomly divided into two groups. Magnesium group received intravenous magnesium after induction of anesthesia (30 mg/kg), then infused until the end of the surgical procedure (9 mg/kg). The placebo group received the same volume of saline infusion. The VAS score was used for postoperative pain assessment, and the Quality of Recovery-40 (QoR-40) score was used for the assessment of recovery status.

Results

The postoperative 30 min, 1st, 2nd, 4th (p < .001) and 24th hour (p < .05) VAS scores of the patients in the magnesium infusion group were significantly lower compared to the placebo group. Also; in terms of physical comfort (p < .001), emotional state (p < .05), psychological support, pain and total score values (p < .001), patients in magnesium group had significantly higher QoR-40 scores than those in placebo group.

Conclusion

Intraoperative magnesium infusion, which is widely used in many surgeries to provide controlled hypotension, also contributes significantly to patient comfort with its positive effect on postoperative pain and recovery scores.

Chinese Abstract

背景

鼻中隔整形术的术后疼痛是影响患者舒适度的重要因素。

目的

探讨围手术期静脉输注硫酸镁对鼻中隔整形术患者的术后疼痛和恢复质量的影响。

材料和方法

将 120 名接受鼻中隔整形术的患者随机分为两组。 镁组麻醉诱导后(30mg/kg)静脉注射镁, 然后输注(9mg/kg)直至手术结束。 安慰剂组给予等量生理盐水输注。 VAS评分用于术后疼痛评估, 并使用恢复质量-40(QoR-40)评分来评估恢复状况。

结果

与安慰剂组相比, 镁输注组患者的术后 30 分钟、第 1、第 2、第 4 (p<.001) 和 第24 小时 (p<.05)的 VAS 评分低很多。而且, 关于身体舒适度 (p<.001)、情绪状态 (p<.05)、心理支持、疼痛和总评分值 (p<.001), 镁组患者的 QoR-40 评分显著高于安慰剂组。

结论

术中镁输注广泛应用于许多手术中, 以提供控制性低血压。它也显著提高了患者的舒适度, 对术后疼痛和恢复评分起着良好作用。

Keywords:

• Septorhinoplasty
• magnesium sulphate
• postoperative pain
• QoR-40

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethical Committee of the Medical Faculty of Ataturk University (No.2021;01).

Informed consent

Informed consent was obtained from all individual participants included in the study.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by Research Fund of the Ataturk University, Erzurum, Turkiye with Project Number: TSA-2022-10490.