ESTRUS PHASE DIFFERENCES IN FEMALE RATS IN MORPHINE ANTINOCICEPTION ELICITED FROM THE VENTROLATERAL PERIAQUEDUCTAL GRAY

RANDI SHANE Department of Social Sciences and Psychology Bronx Community College, City University of New York, Flushing, NY, 11367, USA; Department of Psychology Queens College The Graduate Center, City University of New York, Flushing, NY, 11367, USA; Neuropsychology Doctoral Sub-Program The Graduate Center, City University of New York, Flushing, NY, 11367, USA

SONIA Y. BERNAL Department of Psychology Queens College The Graduate Center, City University of New York, Flushing, NY, 11367, USA; Neuropsychology Doctoral Sub-Program The Graduate Center, City University of New York, Flushing, NY, 11367, USA

SHOSHANA ROZENGURTEL Department of Psychology Queens College The Graduate Center, City University of New York, Flushing, NY, 11367, USA

RICHARD J. BODNAR Department of Psychology Queens College The Graduate Center, City University of New York, Flushing, NY, 11367, USA; Neuropsychology Doctoral Sub-Program The Graduate Center, City University of New York, Flushing, NY, 11367, USA

Abstract

Male rodents display greater systemic morphine antinociception than females which show their most marked effects during late diestrus or proestrus. Morphine (1–2.5 μg) antinociception on the tail-flick test elicited from the ventrolateral periaqueductal gray was examined across estrus phases in female relative to male rats. Morphine antinociception was greatest in magnitude and potency in males followed by females tested during the proestrus phases relative to estrus and met-diestrus. These data confirm morphine's systemic effects, implicate the ventrolateral periaqueductal gray in estrus phase-mediated effects, and underscore the control of the phase of the estrus cycle in examining sex differences in opioid antinociception.

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ESTRUS PHASE DIFFERENCES IN FEMALE RATS IN MORPHINE ANTINOCICEPTION ELICITED FROM THE VENTROLATERAL PERIAQUEDUCTAL GRAY

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ESTRUS PHASE DIFFERENCES IN FEMALE RATS IN MORPHINE ANTINOCICEPTION ELICITED FROM THE VENTROLATERAL PERIAQUEDUCTAL GRAY

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