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International Journal of Neuroscience Volume 118, 2008 - Issue 5
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Original

The Effects of Antidepressants in Parkinson’s Disease: A Meta-Analysis

Pasquale G. Frisina Leir Parkinson's Disease Program, The Jewish Home and Hospital Lifecare System, New York, New York, USA; Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York, USA
,
Harriet R. Tenenbaum Department of Psychology, Kingston University, Kingston upon Thames, United Kingdom
,
Joan C. Borod Department of Psychology, Queens College and The Graduate Center of the City, University of New York, Flushing, New York, USA; Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA
&
Nancy S. Foldi Department of Psychology, Queens College and The Graduate Center of the City, University of New York, Flushing, New York, USA; Division of Geriatrics, Department of Medicine, Winthrop-University Hospital SUNY Stony Brook School of Medicine, Stony Brook, New York, USA
Pages 667-682 | Received 30 Oct 2006, Published online: 07 Jul 2009
 
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Abstract

This study explored the therapeutic effect of antidepressants in Parkinson's disease (PD) using a meta-analysis. Altogether, 24 placebo-controlled trials qualified for inclusion and revealed that tricyclic antidepressants (TCAs) had a greater antidepressant effect relative to selective serotonin reuptake inhibitors (SSRIs), Qb(1) = 8.87, p < .01, and the mono-amine-oxidase inhibitor, selegiline, Qb(1) = 7.90, p < .01. Whereas TCAs produced a significant side effect profile (odds ratio = 3.07), adverse events were negligible with SSRIs (odds ratio = 1.83) and selegeline (odds ratio = 1.63). Antidepressants can be beneficial for patients with PD. However, the choice of antidepressants needs to take depressive symptomatologies into account while monitoring side effects.

Notes

*Indicates studies included in this meta-analysis.

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