Amitriptyline Treatment Under Chronic Stress Conditions: Effect on Circulating Catecholamines and Anxiety in Early Maternally Separated Rats

Abstract

The aim of this work was to determine the effect of amitriptyline (AMI) on peripheral outcomes such as plasma epinephrine (E) and norepinephrine (NE) concentration and anxiety-like behavior displayed in the plus maze test in adult male Wistar rats under variable chronic stress and daily oral administration of AMI (5 mg/kg). Animals were previously isolated from the mother for 4.5 hr every day for the first 3 weeks of life. Administration of the antidepressant AMI reduced anxiety-like behavior in animals submitted only to chronic stress but not in early maternally separated (MS) subjects or in animals subjected to the two types of stresses.

Keywords:

• amitriptyline
• anxiety
• catecholamines
• early maternal separation
• plus maze test
• variable chronic stress