Interactions between four gene polymorphisms and their association with patients with Parkinson's disease in a Chinese Han population

ABSTRACT

The four previously reported Parkinson's disease (PD)-related single-nucleotide polymorphisms (SNPs) – rs1775143, rs823114, rs2071746 and rs62063857 – have rarely been studied in Chinese Han populations. To examine the association between these SNPs and PD, we conducted a case-control study of 158 patients with PD and 210 controls. All participants were Chinese Han from Northern China. With covariate adjustment for clinical characteristics, logistic regression analysis revealed no differences in genotype or allele frequencies for the four SNPs. Stratified by age of disease onset, sex, smoking status, duration of disease, baseline UPDRS, Hoehn–Yahr Stage, PD subtypes, scores of Hamilton anxiety scale, Hamilton depression scale and activity of daily living, all of the p values did not remain significant after Bonferroni correction. However, the haplotype rs1775143T-rs823114G-rs2071746T-rs62063857A was associated with increased risk of developing PD (p = 0.003, OR = 456.88, 95% CI: 27.40–7619.75) in our case-control sample set. The haplotype rs1775143T-rs823114G-rs2071746T was also associated with increased risk of developing PD (p = 0.003, OR = 338.43, 95% CI: 20.68–5538.27). Although the haplotype rs1775143T-rs823114G-rs62063857A was associated with increased risk of PD (p = 0.03), the 95% CI was 0.993–22.469. Our data demonstrate that although specific SNPs were not related with PD patients, certain haplotypes were associated with increased risk for PD in the Chinese Han population. These results provide further evidence that the etiology of PD is multifactorial, although the underling mechanism needs further study.

KEYWORDS:

• Parkinson's disease
• single-nucleotide polymorphism
• rs1775143
• rs823114
• rs2071746
• rs62063857

Acknowledgements

We would like to thank the patients for their participation in this study.

Declaration of Interest

None declared.

This work was supported by the National Natural Science Foundation of China [grant number 81401064], [grant number 81271398]; Science and Technology Development Project of Jining City, Shandong Province, China [grant number 2015jnnk57-28], [grant number 2015jnnk57-50].

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [grant number 81401064], [grant number 81271398]; Science and Technology Development Project of Jining City, Shandong Province, China [grant number 2015jnnk57-28], [grant number 2015jnnk57-50].