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Original Article

Delayed hypersensitivity to cryptococcin in man

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Pages 285-288 | Published online: 09 Jul 2009
 

Abstract

Twenty-six of 82 healthy persons from a small community in Oklahoma responded to intradermal testing with cryptococcin by development of typical delayed skin reactions with induration of 5 mm. or greater in diameter. Although the hyper-reactivity to cryptococcin may be due to past exposure to C. neoformans, exact interpretation of the observed reactions cannot be definite at this time because of concomitant presence of histoplasmin sensitivity in some of the subjects tested.

Zusammenfassung

26 von 82 gesunden Personen aus einer kleinen Gemeinde in Oklahoma zeigten nach intrakutaner Injektion von Cryptococcin eine typische Spätreaktion mit mehr als 5 mm Infiltratdurchmesser. Diese Ueberempfindlichkeit gegen Cryptococcin könnte auf einen früheren Kontakt mit Cryptococcus neoformans zurückgehen, doch ist wegen gleichzeitiger Ueberempfindlichkeit einiger Versuchspersonen gegen Histoplasmin keine sichere Interpretation der Befunde möglich.

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