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Original Article

Requirement of heat-labile opsonins for maximal phagocytosis of Candida albicans

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Pages 293-297 | Published online: 09 Jul 2009
 

Abstract

The requirement for heat-labile opsonins for phagocytosis of 2 serologically distinct strains and a number of clinical isolates of Candida albicans was examined by a previously described radiometric technique. The results indicated that both strains and all 10 isolates of C. albicans examined required heat-labile opsonins for maximal phagocytosis. The data suggest that heatlabile opsonins play an important role in immunity to C. albicans. However, the possibility that some strains of C. albicans may not utilize heat-labile opsonins cannot be excluded.

Zusammenfassung

Vermittels einer zuvor beschriebenen radiometrischen Technik wurde das Bedürfnis an hitzelabilen Opsoninen bei der Phagozytose von 2 serologisch verschiedenen Candida albicans-Stämmen und einer Anzahl von klinisch isolierten Kulturen der gleichen Hefe untersucht. Die Ergebnisse zeigten, daß beide Stämme und alle 10 isolierten Candida albicans-Hefen hitzelabile Opsonine brauchen, um eine maximale Phagozytose zu erreichen. Die Ergebnisse sprechen in dem Sinne. daß hitzelabile Opsonine eine wichtige Rolle bei der Immunität der C. albicans spielen. Die Möglichkeit kann jedoch nicht ausgeschlossen werden, daß einige Stämme der C. albicans hitzelabile Opsonine nicht benötigen.

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