Soluble CD163: a marker molecule for monocyte/macrophage activity in disease

H. J. Møller Department of Clinical Biochemistry, Aarhus University Hospital, Denmark; Department of Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands; Department of Hepatology and Gastroenterology V, Aarhus University Hospital, Denmark;

H. Aerts Department of Clinical Biochemistry, Aarhus University Hospital, Denmark; Department of Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands; Department of Hepatology and Gastroenterology V, Aarhus University Hospital, Denmark;

H. Grøbæk Department of Clinical Biochemistry, Aarhus University Hospital, Denmark; Department of Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands; Department of Hepatology and Gastroenterology V, Aarhus University Hospital, Denmark;

N. A. Peterslund Department of Clinical Biochemistry, Aarhus University Hospital, Denmark; Department of Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands; Department of Hepatology and Gastroenterology V, Aarhus University Hospital, Denmark;

P. Hyltoft Petersen Department of Haematology B, Aarhus University Hospital, Denmark; Department of Clinical Biochemistry, Odense University Hospital, Denmark; Department of Clinical Biochemistry, Randers Central Hospital, Denmark; Department of Endocrinology and Metabolism C, Aarhus University Hospital, Denmark; Department of Medical Biochemistry, University of Aarhus, Denmark

N. Hornung Department of Clinical Biochemistry, Aarhus University Hospital, Denmark; Department of Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands; Department of Hepatology and Gastroenterology V, Aarhus University Hospital, Denmark;

L. Renjmark Department of Haematology B, Aarhus University Hospital, Denmark; Department of Clinical Biochemistry, Odense University Hospital, Denmark; Department of Clinical Biochemistry, Randers Central Hospital, Denmark; Department of Endocrinology and Metabolism C, Aarhus University Hospital, Denmark; Department of Medical Biochemistry, University of Aarhus, Denmark

E. Jabbarpour Department of Haematology B, Aarhus University Hospital, Denmark; Department of Clinical Biochemistry, Odense University Hospital, Denmark; Department of Clinical Biochemistry, Randers Central Hospital, Denmark; Department of Endocrinology and Metabolism C, Aarhus University Hospital, Denmark; Department of Medical Biochemistry, University of Aarhus, Denmark

S. K. Moestrup Department of Haematology B, Aarhus University Hospital, Denmark; Department of Clinical Biochemistry, Odense University Hospital, Denmark; Department of Clinical Biochemistry, Randers Central Hospital, Denmark; Department of Endocrinology and Metabolism C, Aarhus University Hospital, Denmark; Department of Medical Biochemistry, University of Aarhus, Denmark

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Abstract

By immunoprecipitation we have identified a soluble plasma form of CD163 (sCD163), the IL-6 inducible macrophage-receptor for clearing haptoglobinhaemoglobin complexes. A sandwich ELISA for measuring sCD163 was established and used to determine the sCD163 levels in normal subjects and patients with inflammatory and myeloproliferative diseases. In normal subjects, the concentration of sCD163 was high (median 1.9 mg/l) with low intraindividual variation. Highly increased levels were seen in patients with sepsis, myeloid leukaemia and in patients with Gaucher disease characterized by accumulation of tissue macrophages. Although the physiological role of sCD163 remains unknown, our present data suggest that sCD163 might prove to be a valuable marker molecule in infectious and myeloproliferative diseases.

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Soluble CD163: a marker molecule for monocyte/macrophage activity in disease

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Soluble CD163: a marker molecule for monocyte/macrophage activity in disease

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