Elimination of C¹⁴-Histamine Farom the Blood in Man

H. Arnoldsson Department of Allergology, Clinical Physiology, Internal Medicine I and II Roentgenology I and Surgery II, Sahlgren's Hospital and Lillhagen's Mental Hospital, Göteborg, Sweden

C. G. Helander Department of Allergology, Clinical Physiology, Internal Medicine I and II Roentgenology I and Surgery II, Sahlgren's Hospital and Lillhagen's Mental Hospital, Göteborg, Sweden

E. Helander Department of Allergology, Clinical Physiology, Internal Medicine I and II Roentgenology I and Surgery II, Sahlgren's Hospital and Lillhagen's Mental Hospital, Göteborg, Sweden

S. E. Lindell Department of Allergology, Clinical Physiology, Internal Medicine I and II Roentgenology I and Surgery II, Sahlgren's Hospital and Lillhagen's Mental Hospital, Göteborg, Sweden

B. Lindholm Department of Allergology, Clinical Physiology, Internal Medicine I and II Roentgenology I and Surgery II, Sahlgren's Hospital and Lillhagen's Mental Hospital, Göteborg, Sweden

O. Olsson Department of Allergology, Clinical Physiology, Internal Medicine I and II Roentgenology I and Surgery II, Sahlgren's Hospital and Lillhagen's Mental Hospital, Göteborg, Sweden

B. E. Roos Department of Allergology, Clinical Physiology, Internal Medicine I and II Roentgenology I and Surgery II, Sahlgren's Hospital and Lillhagen's Mental Hospital, Göteborg, Sweden

A. Svanborg Department of Allergology, Clinical Physiology, Internal Medicine I and II Roentgenology I and Surgery II, Sahlgren's Hospital and Lillhagen's Mental Hospital, Göteborg, Sweden

B. Söderholm Department of Allergology, Clinical Physiology, Internal Medicine I and II Roentgenology I and Surgery II, Sahlgren's Hospital and Lillhagen's Mental Hospital, Göteborg, Sweden

H. Westling Department of Allergology, Clinical Physiology, Internal Medicine I and II Roentgenology I and Surgery II, Sahlgren's Hospital and Lillhagen's Mental Hospital, Göteborg, Sweden

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Abstract

The removal of injected C¹⁴-labelled histamine from the blood in various tissues has been studied in man. An intravenous infusion of C¹⁴-histamine was given at a constant rate until a steady state had been obtained and samples of arterial blood taken simultaneously with samples of blood from the pulmonary artery, the hepatic, renal, internal, jugular. iliac or axillary veins.

The largest extraction of C¹⁴-histamine from the arterial blood occurred in the renal and the portal circulation.

There was no measurable extraction of C¹⁴-histamine from the blood during its passage through the lungs or the brain.

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Elimination of C¹⁴-Histamine Farom the Blood in Man