The Effect on Different Clotting Factors of Short-Term Treatment with Phenylindanedione

Abstract

A study was made on the effect of short-term treatment with phenylindanedione (P.I.D.) on plasma clotting system, with special regard to antihemophilic A factor (AHA) and antihemophilic C factor (AHC).

Three normal adult males were put on P.I.D. treatment for two weeks, and followed with blood samples from before start to 10 days after the treatment. The treatment was controlled by the Thrombotest (T-T) method, aiming to keep the T-T values at about 15 per cent. Cephalin time, thromboplastin time and a number of clotting factors were assayed in the plasma samples. Correspondingly, six patients with atherosclerotic disease were followed with tests of plasma coagulation system during the first weeks of treatment with P.I.D. For special study of AHA variations, four additional cases with advanced atherosclerotic disease were investigated at the start of the anticoagulant treatment.

The investigations gave the following results: After two weeks of treatment of the normal persons, both cephalin time, thromboplastin time and the clotting factors affected by the treatment, returned to about pretreatment level without showing any marked rebound phenomenon.

The measurements of AHA gave very varying results. AHA could not be shown definitely to decrease, or generally increase by anticoagulant treatment of normal persons or patients with mild atherosclerotic disease. In patients with advanced atherosclerotic disease, a tendency to temporary rise in AHA concentrations during the first days of treatment was observed.

The levels of AHC did not seem to be definitely affected by anticoagulant treatment.

Proaccelerin and fibrinogen measurements gave varying results. No certain conclusions could be drawn about these factors from the limited material.

Antihemophilic B factor (AHB), proconvertin and prothrombin (+Stuart-Prower factor) showed a decrease as an effect of treatment, in accordance with the findings of other workers.