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Abstract
The level of cystathionine was investigated in tissue from four functional neural tumors, in one adrenal-cortical carcinoma, and in the brain, cortex, liver, kidney, adrenals, and thyroid.
The level of cystathionine in the brain was similar to the level in the tumors in three cases of adrenal neuroblastoma with extensive metastases. The same three cases had a pronounced cystathioninuria with a cystathionine excretion of 240–900 μg per mg of creatinine.
One case of ganglio-neuroblastoma had a much lower level of cystathionine both in the tumor and in the urine.
The adrenal-cortical carcinoma did not contain any cystathionine at all.
The liver, kidney, adrenals, and thyroid contained only about 1/10 of the cystathionine content of the brain.
The tumor tissue contained only about 1/12 of the amount of y-amino-butyric acid found in the brain.
Cystathionine is normally not present in urine of children or adults. Cystathioninuria seems to be present in patients with functional neural tumors and provide information about the malignancy of these tumors.
The more cystathionine in the urine, the more malignant is the tumor with metastases.