Relationship Between Serum Concentration and Urinary Output of Trypsin Inhibitor After Cortisone Administration

Abstract

The time-response relationship between a single oral dose of cortisone acetate and the urinary trypsin inhibitor output was studied in 4 persons receiving long-term treatment with glucocorticoid. A lag period of 4 hours was observed before the increase in output occurred.

In the same persons the serum concentrations of trypsin inhibitor were followed, demonstrating increases simultaneously with the urinary increases.

The findings support the assumption that the urinary trypsin inhibitor originates from serum and that the urinary output of this inhibitor reflects variations of the concentration of the same inhibitor in serum.