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Scandinavian Journal of Clinical and Laboratory Investigation Volume 47, 1987 - Issue 4
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Original Article

Analysis of serum concentration of phenobarbital, phenytoin, carbamazepine and carbamazepine 10,11-epoxide by solvent-recycled liquid chromatography

Arne Åsberg Central Laboratory, Psykiatrisk avd Buskerud Sentralsykehus, Lier, Norway
&
Frode Haffner Central Laboratory, Psykiatrisk avd Buskerud Sentralsykehus, Lier, Norway
Pages 389-392 | Received 28 Aug 1986, Accepted 06 Nov 1986, Published online: 17 Mar 2010
 
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Abstract

A rapid and precise low cost method for analysing phenobarbital, phenytoin, carbamazepine and carbamazepine 10,11-epoxide using liquid chromatography is described. Recycling reduced the mobile phase consumption by 75%. Recovery was 97.7–101.4% and between days CV was 1.3–1.7%. The retention times of potentially interfering substances are listed.

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