Insulin treatment reduces the increased serum and lung angiotensin converting enzyme activity in streptozotocin-induced diabetic rats

A. Erman Institute of Nephrology and Hypertension, and

B. Chen-Gal Institute of Nephrology and Hypertension, and

I. David Institute of Nephrology and Hypertension, and

S. Giler Experimental Surgery Unit, Felsenstein Research Center, Rabin Medical Center (Beilinson Campus), and Sackler School of Medicine, Tel-Aviv University, Petah-Tikva, Israel

G. Boner Institute of Nephrology and Hypertension, and

D. J. Van Dijk Institute of Nephrology and Hypertension, and

Abstract

Serum and lung angiotensin-converting enzyme (ACE) activity is increased in the streptozotocin (STZ)-diabetic rat. In the present study, the effect of insulin treatment on this increased ACE activity in the STZ-diabetic rat was investigated. Serum and tissue ACE activity was determined by radiometric assay using [³H]-Hippuryl-glycyl-glycine as substrate. Fifteen days after onset of diabetes (n = 16), 8 rats received insulin daily (6 - 12 units/kg, s.c.) for 33

Keywords

Diabetes Kininase Ii

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Insulin treatment reduces the increased serum and lung angiotensin converting enzyme activity in streptozotocin-induced diabetic rats

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Insulin treatment reduces the increased serum and lung angiotensin converting enzyme activity in streptozotocin-induced diabetic rats

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