Abstract
Background: Helicobacter pylori has been found to be only a minor risk factor for gastroduodenal complications in kidney transplantation patients. The aim of the study was to follow up the course of H. pylori infection in a group of immunosuppressed kidney transplantation patients. Methods: After a median follow-up of 6.8 years, control serum samples were taken from 93 originally seropositive and 88 originally seronegative kidney transplant recipients. H. pylori antibodies of the IgG and IgA classes and serum pepsinogen I levels were measured from pretransplant and follow-up samples in parallel. In addition, CagA antibodies were measured from the baseline samples of the seropositive patients. Results: 83 of the 93 seropositive patients were also cagA-positive. In addition to the 10 patients who received H. pylori eradication therapy, 27 (29%) of the 92 patients with originally elevated H. pylori IgG antibody titres showed IgG titres at normal level or levels decreased by more than 70% and below 2000 (regarded as seroreverters) after the follow-up. One of the originally seronegative patients seroconverted during the study period. After transplantation, the decrease of serum pepsinogen I values was in accordance with improved kidney function. Patients with lower serum pepsinogen I levels before the transplantation seroreverted more easily. Conclusions: A spontaneous H. pylori seroreversion occurred in 29% of the immunosuppressed kidney transplantation patients. After a successful kidney transplantation, serum pepsinogen I values declined significantly.
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S. Sarkio
Sarkio S, Rautelin H, Halme L. The course of Helicobacter pylori infection in kidney transplantation patients. Scand J Gastroenterol 2003; 38:20–26.
H. Rautelin
Sarkio S, Rautelin H, Halme L. The course of Helicobacter pylori infection in kidney transplantation patients. Scand J Gastroenterol 2003; 38:20–26.
L. Halme
Sarkio S, Rautelin H, Halme L. The course of Helicobacter pylori infection in kidney transplantation patients. Scand J Gastroenterol 2003; 38:20–26.