Recent advances in the knowledge of the mechanism of reflux hypersensitivity

Abstract

Reflux hypersensitivity (RH) is a subtype of gastroesophageal reflux disease. The Rome IV criteria separated RH from the original nonerosive reflux disease subgroup and classified it as a new functional oesophageal disease. Recently, the pathogenesis of RH has become the focus of research. According to the latest research reports, upregulation of acid-sensitive receptors, distribution of calcitonin gene-related peptide-positive nerve fibres, and psychiatric comorbidity have key roles in the pathogenesis of RH. This work reviews the latest findings regarding RH mechanisms.

Keywords:

• Reflux hypersensitivity
• calcitonin gene-related peptide
• transient receptor potential vanilloid 1
• proteinase-activated receptor 2
• acid-sensing ion channels

Acknowledgments

We thank the patients who provided the data for above studies.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by a grant from Key project of Zhejiang Medical and Health Major Science and Technology Plan (grant no. WKJ-ZJ-2018).