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Scandinavian Journal of Gastroenterology Volume 33, 1998 - Issue 2
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Research Article

Large Intravenous Bilirubin Loads Increase the Cytotoxicity of Bile and Lower the Resistance of the Canalicular Membrane to Cytotoxic Injury and Cause Cholestasis in Pigs

B. A. BJØRNBETH, M. ENDRESEN, E. HVATTUM, T. LYBERG, O. VILLANGER, M. G. RÆDER
Pages 201-208 | Published online: 08 Jul 2009
 
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Abstract

Background: Large intravenous bilirubin loads cause loss of hepatic canalicular membrane microvilli and cholestasis. This study examines whether these untoward effects might be due to canalicular membrane injury from cytotoxic bile. Methods

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