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Scandinavian Journal of Infectious Diseases Volume 33, 2001 - Issue 10
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Research Article

Development of Live Recombinant Vaccine Candidates Against Tuberculosis

Jürgen Hess From the Max - Planck - Institute for Infection Biology , Department of Immunology , Berlin , Germany
&
Stefan H. E. Kaufmann From the Max - Planck - Institute for Infection Biology , Department of Immunology , Berlin , Germany
Pages 723-724 | Published online: 08 Jul 2009
 
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Abstract

We report on 2 recombinant (r) live vaccine candidates that use different strategies to improve cell-mediated immunity for TB control: (i) the current TB vaccine strain Mycobacterium bovis BCG, endowed with a pore-forming cytolysin; and (ii) rSalmonella typhimurium secreting a single immunodominant antigen shared by BCG and M. tuberculosis.

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